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|Purity:||Tranexamic Acid||Grade Standard:||Medicine Grade|
|Usage:||Animal Pharmaceuticals||Assay:||HPLC 99%|
arachidonic acid powder,
docosahexaenoic acid powder
Synonym: TIMTEC-BB SBB006715; TRANS-4-AMINOMETHYL-1-CYCLOHEXANECARBOXYLIC ACID; Trans-4-aminomethylcyclohexane-1-carboxylate; TRANS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLIC ACID; TRANEXAMIC ACID; Amstat; Amcha; Amikapron
Appearance: White powder
Chemical Property: To aminomethylbenzoic acid tranexamic acid derivatives, is a kind of antifibrinolytic drugs to stop bleeding, hemostasis and aminocaproic acid, tranexamic acid, but the effect is stronger, strength is 7 ~ 2 amino acid 10 times, aminomethylbenzoic acid, and similar in toxicity.
The development and fibrinolytic phenomena associated with the body heal under physiological or pathological state of fibrinolysis, increased vascular permeability, etc., but also on the body caused by reaction with fibrinolysis, a variety of symptoms and allergic reactions such as bleeding. This product can inhibit plasmin, and display bleeding, anti-allergic, anti-inflammatory effect.
Tranexamic acid can be combined with the plasmin and plasminogen and fibrin affinity site lysine site (LBS) is strongly adsorbed by inhibition of plasmin, plasminogen and fibrin binding and thus strongly inhibit fibrin by plasmin-induced decomposition; Addition, in the presence of serum and other anti-plasmin macroglobulin, tranexamic acid antifibrinolytic effect is more obvious.
|Test Items||Specification||Test Results|
|Appearance||White crystalline powder||White crystalline powder|
|Solubility||Soluble in water and glacial acetic acid, almost not soluble in ethanol and acetone (96%)||Soluble in water and glacial acetic acid, almost not soluble in ethanol and acetone (96%)|
|Identification||Infrared absorption map complies with the tranexamic acid comparison map||Infrared absorption map complies with the tranexamic acid comparison map|
|Loss on drying||≤0.5%||0.09%|
|Residue on ignition||≤0.1%||0.01%|
|A≤0.1%, B≤0.2% C ≤ 0.1%, D ≤ 0.1%
Total impurities(except A,B) ≤0.2%
|A≤0.1%, B≤0.2% C ≤ 0.1%, D ≤ 0.1%
Total impurities(except A,B)=0.015%
|Conclusion||Complies with BP2012|
1. Hemostatic, significant effect on traumatic bleeding, preoperative prophylactic medication can decrease operation hemorrhage.
2. The chemical structure of tranexamic acid and lysine, competitive inhibition of plasminogen to fibrin adsorption, to prevent their activation, protect the fiber protein was not degraded by the enzyme and dissolved, ultimately achieve hemostasis effect.
3. All applicable in the treatment of acute or chronic, localized or systemic primary fibrinolysis hyperfunction caused by bleeding, such as obstetric hemorrhage, renal hemorrhage, hypertrophy of the prostate, hemophilia hemorrhage, pulmonary tuberculosis hemoptysis, bleeding in the stomach, liver, lung, spleen and other organs of hemorrhage after operation
4. The clinical effect of tranexamic acid on insect bites, eczema and dermatitis, simple purpura, chronic urticaria, artificial sex urticaria, rash and drug poisoning effect, also have certain effects on erythroderma, scleroderma, SLE, erythema multiforme, herpes zoster and alopecia areata, curative effect of hereditary angioedema is also good.
Tranexamic acid for aminomethylbenzoic acid derivatives, is a kind of fibrinolytic hemostatic drug resistance, hemostatic mechanism with the same amino caproic acid, aminomethylbenzoic acid, but the effect is stronger, the intensity of 7 ~ 10 times that of amino caproic acid, aminomethylbenzoic acid 2 times, and similar toxicity. Tranexamic acid structure similar to the lysine, can be competitive inhibitory fibrinolytic enzyme on the fibrous protein adsorption, prevent its activation, protect the fibrin degradation by fibrinolytic enzyme and dissolved, ultimately achieve hemostatic effect. Limitations are suitable for the treatment of acute or chronic, or systemic primary fibrinolysis hyperfunction caused by all kinds of bleeding, such as the obstetric hemorrhage, renal hemorrhage, prostatic hypertrophy, hemorrhage, hemophilia, tuberculosis, coughing up blood, stomach bleeding, liver, lung, spleen and other visceral bleeding after the operation, etc; When the operation can also be used for abnormal bleeding and so on.
Tranexamic acid is frequently used in surgeries with high risk of blood loss such as cardiac, liver, vascular and large orthopedic procedures. Its oral form is now being evaluated for use in outpatient conditions involving heavy bleeding.
Tranexamic acid has been found to decrease the risk of death in people who have significant bleeding due to trauma. However, it may actually increase the risk of death due to bleeding if administered more than 3 hours after the injury.
Tranexamic acid is commonly used in cardiac surgery, both with and without cardiopulmonary bypass. It replaces aprotinin.
Tranexamic acid is used in orthopedic surgery to reduce bloodloss. It is of proven value in clearing the field of surgery and reducing pre- and postoperative blood loss. Drain and number of transfusions are reduced.
Used as firstline nonhormonal treatment of dysfunctional uterine bleeding, and heavy bleeding associated with uterine fibroids. A recent study showed patients treated with tranexamic acid are more likely to develop thrombosis and necrosis in their fibroids, and may result in pain and fever.
Tranexamic acid is used in dentistry in the form of a 5% mouth rinse after extractions or surgery in patients with prolonged bleeding time, e.g. from acquired or inherited disorders.
Other usesIn obstetrics, tranexamic acid is used after delivery to reduce bleeding, often with syntocinon/oxytocin and fundal massage.
Tranexamic acid is also useful in the treatment of bleeding as a second line treatment after factor VIII in patients (e.g. tooth extraction).
Clinical studies for years have proved that tranexamic acid can dilute spot effectively and rapidly, which helps to demonstrate a perfect white and bright skin. The spot-removing effect of tranexamic acid is about 50 times over Vitamin C, and 10 times over AHA. The concentration limit of usage is 2%-3%, and in cosmetics the amount is around 0.5%
-------------------------------- Additional Information -------------------------------
Place of origin : China
Brand : SMQ
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Minimum order quantity : 1 kg
Production capacity : 1000 Kilograms/Month
-------------------------------- Delivery Information ---------------------------------
Packing : Foil bag/tin or as your request
Payment : T/T, Western Union, MoneyGram
Port : Shanghai, Shenzhen, Hongkong
Shipment method : EMS, DHL, FeDex, UPS, etc
Leading time : Within 24 hours after payment
Delivery time : Within 6 business days after payment (door to door service)
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