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Safe Pharmaceutical Intermediates Anti Aging Hormones Acetate Powdered Cjc-1295 With Dac

Good quality Test Sustanon 250 for sales
Good quality Test Sustanon 250 for sales
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Safe Pharmaceutical Intermediates Anti Aging Hormones Acetate Powdered Cjc-1295 With Dac

China Safe Pharmaceutical Intermediates Anti Aging Hormones Acetate Powdered Cjc-1295 With Dac supplier

Large Image :  Safe Pharmaceutical Intermediates Anti Aging Hormones Acetate Powdered Cjc-1295 With Dac

Product Details:

Place of Origin: China
Brand Name: Simeiquan
Certification: IOS9001
Model Number: 12312

Payment & Shipping Terms:

Minimum Order Quantity: 10vials
Price: 1USD
Packaging Details: Disguised package
Delivery Time: 1-3 working days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000vials pet month
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Detailed Product Description
Purity: 99% Application: Pharm Intermediates
Type: Pharmaceutical Intermediates Appearance: White Powder
Cas No.: 100-83-4 Other Names: Dimethylamine Hydrochloride
Color: White Packing: Customized Packing
Shelf Life: 2 Years
High Light:

pharmaceutical raw materials

,

pharmaceutical active ingredients


1. Quick Detail:

Unit Size :2 mg/vial
Unit Quantity :1 Vial
CAS NO. :863288-34-0
Synonyms :CJC1295/DAC, CJC-1295 with dac, CJC 1295
Molecular Formula :C165H269N47O46
Molecular Weight :3647.19
Sequence :H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Mal)-NH2
Appearance :White Powder
Purity :98.71%
Identity (ESI-MS) :3647.19±3.0
Source :Chemical Synthesis
Storage :Lyophilized CJC-1295 W/ DAC is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting CJC-1295 W/ DAC should be refrigerated at temperatures not to exceed 36 F.

2. Description:

CJC-1295 is a derivative of human GH-releasing factor1-29(HGRF1-29). HGRF1-29 is a naturally occurring peptide that is actually a truncated form of a larger peptide that binds to the growth hormon secretagogue receptor (GHS-R) and causes the release of growth hormon. CJC-1295 has four amino acids substituted in its chain that result in strong binding to serum albumin and prolong its half-life in the body.

Because of the way CJC-1295 is engineered its half life has been extended from ~7 minutes to greater than 7 days!. This is convenient as it means the product only needs to be injected 1-2 times per week for continuously elevated levels of Human Growth Hormon (HG*) and IG*-1. A single subcutaneous (sc) injection results in measurable quantities of CJC-1295 in the blood for up to 13 days. Additionally, a single dose of 60 ug/kg of CJC-1295 results in elevated levels of growth hormon (125%) while the pulsatile secretion of GH is maintained. Furthermore, 60 ug/kg of CJC-1295 elevated IG*-1 levels to the upper limit of normal. A dose of 30 ug/kg of CJC-1295 given weekly maintained its response with no evidence of desensitization.
The advantage of using CJC-1295 instead of actual HG* injections is that injecting HG* shuts down the body's own natural production and therefore when injections are ceased, the body's ability to produce it's own HG* may be impaired and take some time to recover. Since CJC-1295 only stimulates the body's own HG* production, this risk is not apparent.
Another very positive benefit of CJC-1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS are decreased significantly in older adults and also with people who tend to exercise later in the evening. This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.
Clinical Research was first conducted for CJC-1295 during the mid-2000s. The objective of the peptide was to treat visceral fat deposits in obese AIDS patients, as increased levels of exogenous hg* are presumed to increase lipolysis (fat loss). The clinical research was ultimately successful for most research subjects.

3. Applications:

Those looking for anti-aging benefits, improved physique and sense of well being.
Administration of single doses of CJC-1295 resulted in a 2- to 10-fold increase in mean serum GH levels in all dosing groups, which was dose incremental and persisted for up to 6 days. Similarly, a dose-related increase in mean serum IG*-I levels was observed at all dose levels, ranging from 1.5- to 3-fold and persisting for up to 14 days. Administration of ascending multiple doses of CJC-1295 resulted in elevated levels of GH, similar to those observed after a single dose.

In contrast, elevations in IG*-I levels showed a progressive effect over time, particularly in subjects receiving CJC-1295 every 7 d. Results of the multiple-dose study suggest both a cumulative pharmacokinetic effect [i.e. persistence of elevated predose levels of IG*-I in all dosing groups except group 1 (i.e. two injections of 30 µg/kg)] and a pituitary priming effect (i.e.progressively greater Cmax and progressively shorter Tmax after serial dosing). The data indicate that a minimum dosing interval of 7 d appears reasonable. The most appropriate dosing interval will be determined based on actual efficacy and safety data from longer-term therapeutic studies in patients with various clinical conditions.
No serious adverse reactions were reported in either study. The most frequently reported adverse events in subjects receivingCJC-1295 were injection site reactions, consisting of transient pain, swelling, and induration that were sometimes accompanied by local urticaria. Injection site reactions tended to be more severe and/or prolonged at higher dose levels. Headache, diarrhea, and flushing were also observed, with occasional transient and mild hypotension, but occurred primarily at higher doses.
Adverse effects complicate the use of GH in the treatment of HIV-associated metabolic conditions such as wasting and lipodystrophy. Although increases in the daily dose of GH from 1 to 6 mg are associated with dose-responsive benefits, doses of 2-3 mg/d or greater are associated with edema, arthralgias, and glucose intolerance. These side effects can become dose limiting. In the current studies, none of the subjects experienced these adverse effects. Future clinical trials on this disorder will confirm whether the use of GHRH rather than GH will circumvent these problems, as has been suggested in recent publications.

In summary, a single sc administration of CJC-1295 produced sustained elevations of serum GH and IG*-I levels in normal subjects for nearly 2 wk. Weekly or biweekly administration of CJC-1295 resulted in stimulation of GH and IG*-I secretion for at least 7 d. Both single and multiple doses of CJC-1295 over 2 wk were safe and generally well tolerated, particularly at doses of 30 and 60 µg/kg. Future studies are indicated to evaluate the clinical utility of treatment with CJC-1295 in patients with intact GH secretory capacity.

Now for any GH releaser's benefits to reach full potential, somatostatin has to be controlled because it will inhibit gh release. Using an agent known as an Acetylcholinesterase inhibitor will allow acetyl chlorine levels to rise by preventing acethylcholineesterase from overriding acetylcholine; acetylcholine will inhibit somastostatin production. An example of a natural acetylcholinieestarase would be Huzperine A. A recommended dosage for HuzperineA would be around 50mcg. Now as mentioned before a more potent pharm grade somastostatin inhibitor would be Ipamorelin.

Logically speaking it would make PERFECT sense to combine CJC-1295 with Ipamorelin since you get the increase in GH from CJC and the increase of GH pulse frequencies with a reduction in somatostatin from the Ipamorelin. This leads to a maximal GH release effect, thus allowing for maximum anabolism from optimized GH without desensitization.



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