Product Name: Gonadorelin
Synonyms: LUTEINIZING HORMONE-RELEASING HORMONE (SEA BREAM);LUTENIZING HORMONE RELEASING HORMONE HUMAN;LUTEINIZING HORMONE-RELEASING HORMONE (LAMPREY III);LUTEINIZING HORMONE-RELEASING HORMONE (LH-RH), HUMAN;LUTEINIZING HORMONE RELEASING HORMONE HUMAN;LUTEINIZING HORMONE RELEASING HORMONE (HUMAN) PORCINE, RAT;LUTEINIZING HORMONE-RELEASING FACTOR (LAMPREY III);LUTEINIZING HORMONE-RELEASING HORMONEACETATE
Purity (HPLC): ≥98.0%
Function: Gonadorelin is a medicine that is the same as HMG-releasing hormone (GnRH) that is naturally released from the hypothalamus gland.
Storage: a cool(2~8 °C) & dry place
Gonadorelin is another name for HMG-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
GnRH is available as gonadorelin hydrochloride )and gonadorelin diacetate tetrahydrate for injectable use. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.
Gonadorelin is a medicine that is the same as HMG-releasing hormone (GnRH) that is naturally released from the hypothalamus gland.
How does it work?
Gonadorelin is a hormone that is produced naturally by the hypothalamus in the brain. It is also known as gonadotrophin-releasing hormone or GnRH.
Gonadorelin stimulates the pituitary gland in the brain to release the sex hormones luteinising hormone (LH) and follicle stimulating hormone (FSH). In women, FSH stimulates the production of oestrogen and the development of eggs in the ovaries. LH stimulates the ovaries to release an egg (ovulation). In men, LH stimulates the testicles to produce the hormone testosterone and FSH stimulates the testicles to produce sperm.
Gonadorelin is given by injection to check whether the pituitary gland is producing LH and FSH in the correct levels. This can help in the diagnosis of various hormonal disorders, including infertility, delayed puberty and hypogonadism.
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