Wuhan Hezhong Bio-Chemical Manufacture Co., Ltd.

Choosing A Professional Supplier Will Get Twice The Result !

Home
Products
About Us
Factory Tour
Quality Control
Contact Us
Request A Quote
Home ProductsPharmaceutical Intermediates

Donepezil HCl Pharmaceutical Intermediates Nootropics Powder CAS 120011 70 3 Purity 99%

Good quality Test Sustanon 250 for sales
Good quality Test Sustanon 250 for sales
I'm Online Chat Now

Donepezil HCl Pharmaceutical Intermediates Nootropics Powder CAS 120011 70 3 Purity 99%

China Donepezil HCl Pharmaceutical Intermediates Nootropics Powder CAS 120011 70 3 Purity 99% supplier
Donepezil HCl Pharmaceutical Intermediates Nootropics Powder CAS 120011 70 3 Purity 99% supplier Donepezil HCl Pharmaceutical Intermediates Nootropics Powder CAS 120011 70 3 Purity 99% supplier Donepezil HCl Pharmaceutical Intermediates Nootropics Powder CAS 120011 70 3 Purity 99% supplier Donepezil HCl Pharmaceutical Intermediates Nootropics Powder CAS 120011 70 3 Purity 99% supplier

Large Image :  Donepezil HCl Pharmaceutical Intermediates Nootropics Powder CAS 120011 70 3 Purity 99%

Product Details:

Place of Origin: China
Brand Name: Simeiquan
Certification: IOS9001
Model Number: 213423

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: 10USD
Packaging Details: 25kg Carton box
Delivery Time: 1-3 working days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg per month
Contact Now
Detailed Product Description
Name: Donepezil HCl CAS: 120011-70-3
Purity: 99% Appearance: White Powder
High Light:

active pharmaceutical ingredient

,

pharmaceutical raw materials


Product Name: Donepezil
CAS: 120014-06-4
MF: C24H29NO3
MW: 379.492
Purity: 99%
MP: 207ºC
BP: 527.9°C at 760 mmHg
FP: 273.1°C
Density: 1.141g/cm3
Grade: Pharmaceutical Grade
Appearance: White Powder

 

Description

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.

 

Function

 

Donepezil has been tested in other cognitive disorders including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.

 

A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia.

 

Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

 

Mechanism of Action

 

Donepezil binds and reversibly inactivates the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentrations at cholinergic synapses.

 

The precise mechanism of action of donepezil in patients with Alzheimer's disease is not fully understood. Certainly Alzheimer's disease involves a substantial loss of the elements of the cholinergic system and it is generally accepted that the symptoms of Alzheimer's disease are related to this cholinergic deficit, particularly in the cerebral cortex and other areas of the brain. It is noted that the hippocampal formation plays an important role in the processes of control of attention, memory and learning. Just the severity of the loss of cholinergic neurons of the central nervous system (CNS) has been found to correlate with the severity of cognitive impairment.

 

In addition to its actions as an acetylcholinesterase inhibitor, donepezil has been found to act as a potent agonist of the σ1 receptor (Ki = 14.6 nM), and has been shown to produce specific antiamnestic effects in animals mainly via this action.

 

Side Effects

 

In clinical trials the most common adverse events leading to discontinuation were nausea, diarrhea, and vomiting. Other side effects included difficulty sleeping, muscle cramps and anorexia. Most side effects were observed in patients taking the 23 mg dose compared to 10 mg or lower doses. Side effects improved with continued use.



Nootropics

 

Name CAS Purity
CDP-Choline 987-78-0 ≥98% HPLC
Citicoline sodium 33818-15-4 ≥98% HPLC
     
Coluracetam (MKC-231) 135463-81-9 ≥99.0% HPLC
     
Fasoracetam 110958-19-5 ≥99.0% HPLC
Galantamine Hydrobromide 1953-4-4 ≥99.0% HPLC
Huperzine A 102518-79-6 ≥1.0% and 99% HPLC
Armodafinil 112111-43-0 ≥99.0% HPLC
     
adrafinils 63547-13-7 ≥99.0% HPLC
Hydrafinil (9-Fluorenol) 1689-64-1 ≥99.0% HPLC
L-Alpha glycerylphosphorylcholine/ GPC 28319-77-9 50%, 99% HPLC
Phosphatidylserine 51446-62-9 ≥20%, 50% and 70% HPLC
L-α-Phosphatidylcholine 8002-43-5 70%, 50%
Magnesium L-Threonate 778571-57-6 ≥95.0% Titration
N-Acetyl-L-Tyrosine 537-55-3 98%~102% HPLC
Noopept 157115-85-0 ≥99.0% HPLC
Oxiracetam 62613-82-5 ≥99.0% HPLC
Phenibut 1078-21-3 ≥99.0% HPLC
Phenylpiracetam 77472-70-9 ≥99% HPLC
     
Pikamilone (Sodium) 62936-56-5 ≥98%~101%Titration
Piracetam 7491-74-9 ≥99.0% HPLC
     
Pramiracetam 68497-62-1 ≥98.0~102.0% HPLC
     
Sulbutiamine 3286-46-2 ≥98.0% HPLC
Sunifiram 314728-85-3 ≥99.5% HPLC
Tianeptine Hemisukfate Monohydrate,tianeptine sulfate 66981-73-5 ≥98.0%~102.0% HPLC
Tianeptine sodium 30123-17-2 ≥99.0% HPLC
     
Vincamine 1617-90-9 ≥99.0% HPLC
Vinpocetine 42971-09-5 ≥99.0% HPLC
PRL-8-53 51352-87-5 ≥99.0% HPLC
NSI-189 1270138-40-3 ≥99.0% HPLC
IDRA-21 22503-72-6 ≥99.0% HPLC
Mexidol 127464-43-1 ≥99.0% HPLC
agomelatine 138112-76-2 ≥99.0% HPLC
5a hydroxy laxogenin 56786-63-1 ≥99.0% HPLC
     
tadanafil 171596-29-5 ≥99.0% HPLC
avanafil 330784-47-9 ≥99.0% HPLC
     

 

4. Specification:

Name Specification
MGF 2mg/vials, 10 vials/box
PEG MGF 2mg/vials, 10 vials/box
CJC-1295 with DAC 2mg/vials, 10 vials/box
CJC-1295 without DAC 2mg/vials, 10 vials/box
PT-141 10mg/vials, 10 vials/box
MT-1 10mg/vials, 10 vials/box
MT-2 10mg/vials, 10 vials/box
GHRP-2 5mg/vials, 10 vials/box
GHRP-2 10mg/vials, 10 vials/box
GHRP-6 5mg/vials, 10 vials/box
GHRP-6 10mg/vials, 10 vials/box
Ipamorelin 2mg/vials, 10 vials/box
Hexarelin 2mg/vials, 10 vials/box
Sermorelin 2mg/vials, 10 vials/box
Oxytocin 2mg/vials, 10 vials/box
TB500 2mg/vials, 10 vials/box
pentadecapeptide BPC 157 2mg/vials, 10 vials/box
Hg 176-191 2mg/vials, 10 vials/box
Triptorelin 2mg/vials, 10 vials/box
Tesamorelin 2mg/vials, 10 vials/box
Gonadorelin 2mg/vials, 10 vials/box
Gonadorelin 10mg/vials, 10 vials/box
DSIP 2mg/vials, 10 vials/box
Selank 5mg/vials, 10 vials/box

 

MGF

Name Specification
MGF 2mg/vial
PEG MGF 2mg/vial
CJC-1295 with DAC 2mg/vial
CJC-1295 without DAC 2mg/vial
PT-141 10mg/vial
MT-1(Melanotan) 10mg/vial
MT-2 10mg/vial
GHRP-2 5mg/vial
GHRP-2 10mg/vial
GHRP-6 5mg/vial
GHRP-6 10mg/vial
Ipamorelin 2mg/vial
Hexarelin 2mg/vial
Sermorelin 2mg/vial
Oxytocin 2mg/vial
TB500 2mg/vial
pentadecapeptide BPC 157 2mg/vial
176-191 2mg/vial
Triptorelin 2mg/vial
Tesamorelin 2mg/vial
Gonadorelin 2mg/vial
Gonadorelin 10mg/vial
DSIP 2mg/vial
Selank 5mg/vial

 

CAS:94-24-6 Tetracaine base
CAS:136-47-0 Tetracaine hydrochloride
CAS: 73-78-9 lidocaine hydrochloride
CAS: 137-58-6 Linocaine Base
CAS: 23239-88-5 Benzocaine hydrochloride
CAS:94-09-7 Benzocaine
CAS:59-46-1 Procaine
CAS: 51-05-8 Procaine hydrochloride
CAS: 721-50-6 Prilocaine
CAS: 721-50-6 Prilocaine hydrochloride
CAS: 5875-6-9 Proparacaine hydrochloride
CAS: 637-58-1 Pramoxine hydrochloride
CAS: 614-39-1 Procainamide hydrochloride
CAS: 98717-15-8 Ropivacaine hydrochloride
CAS: 23964-57-0 Articaine hydrochloride



Growth Hormne Peptides

T-A001 MGF 2mg
T-A002 PEG MGF 2mg
T-A003 CJC-1295 with DAC 2mg
T-A004 CJC-1295 without DAC 2mg
T-A005 PT-141 10mg
T-A006 MT-1(Melanotan-1) 10mg
T-A007 MT-2(Melanotan-2) 10mg
T-A008 GHRP-2 5mg
T-A008 GHRP-2 10mg
T-A009 GHRP-6 5mg
T-A009 GHRP-6 10mg
T-A0010 Ipamorelin 2mg
T-A0011 Hexarelin 2mg
T-A0012 Sermorelin 2mg
T-A0013 Oxytocin 1g
T-A0014 TB500 2mg
T-A0015 pentadecapeptide BPC 157 2mg
T-A0016   2mg
T-A0017 Triptorelin 2mg
T-A0018 Tesamorelin 2mg
T-A0020 Gonadorelin 2mg
T-A0020 Gonadorelin 10mg
T-A0021 DSIP 2mg
T-A0022 Selank 5mg
T-A0023 Epitalon 10mg



 

Peptides Specification
MGF 2mg
PEG MGF 2mg
CJC-1295 with DAC 2mg
CJC-1295 without DAC 2mg
PT-141 10mg
MT-1 10mg
MT-2 10mg
GHRP-2 5mg
GHRP-2 10mg
GHRP-6 5mg
GHRP-6 10mg
Ipamorelin 2mg
Hexarelin 2mg
Sermorelin 2mg
Oxytocin 2mg
TB500 2mg
Pentadecapeptide BPC 157 2mg
Triptorelin 2mg
Tesamorelin 2mg
Gonadorelin 2mg
Gonadorelin 10mg
DSIP 2mg
Selank 5mg




Related products
Bodybuilding Steroid Powder/Raw Material Hormone Powder/ Enhances Muscle Steroid Powder:




Epiandrosteron (CAS: 481-29-8)
DHE. A(Dehydroepiandrosteron) (CAS: 53-43-0)




Tadalafi(Ciali) (CAS: 171596-29-5)
(Levitr) (CAS: 224785-91-5)


Weight Loss Powder:

Phentermin Hydrochloride(CAS: 1197-21-3)
L(-)-Carnitine (CAS: 541-15-1)
Rimonabant (CAS: 158681-13-1)



Plant Extract
Tribulus extract (CAS No. 22153-44-2)
Trigonelline (CAS No. 535-83-1)
Curcumin (CAS No. 458-37-7)
Oat Extract (CAS No. 84012-26-0)
Tongkat Ali extract (CAS No. 84633-29-4)
Vitexin (CAS No. 3681-93-4)


-------------------------------- Additional Information -------------------------------
Place of origin : China
Brand : SMQ
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Production capacity : 1000 Kilograms/Month

-------------------------------- Delivery Information ---------------------------------
Packing : Foil bag/tin or as your request
Payment : T/T, Western Union, MoneyGram
Port : Shanghai, Shenzhen, Hongkong
Shipment method : EMS, DHL, FeDex, UPS, etc
Leading time : Within 24 hours after payment
Delivery time : Within 6 business days after payment (door to door service)
-------------------------------- Our Competitive Advantages ---------------------------
1.Please let me know the items you are looking for, quantity, and the destination country.
2. We send the detailed price of our product and offer the suitable shipping method for your reference.
3. You confirm the order and pay money 100% in advance and send us the detailed address.
4.We will pack your parcel and arrange to shipment according to your requirements
5.Once parcel is sent,I will offer you parcel's picture,tracking number and tracking website.
6.After you receiving parcel,we will offer you best after-sale.

 

Contact Details
Wuhan Hezhong Bio-Chemical Manufacture Co., Ltd.

Contact Person: sales

Send your inquiry directly to us (0 / 3000)