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Dectomax Doramectin 99% Purity Veterinary Antibacterial Powder For Anti Parasitic

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Dectomax Doramectin 99% Purity Veterinary Antibacterial Powder For Anti Parasitic

China Dectomax Doramectin 99% Purity Veterinary Antibacterial Powder For Anti Parasitic supplier
Dectomax Doramectin 99% Purity Veterinary Antibacterial Powder For Anti Parasitic supplier Dectomax Doramectin 99% Purity Veterinary Antibacterial Powder For Anti Parasitic supplier

Large Image :  Dectomax Doramectin 99% Purity Veterinary Antibacterial Powder For Anti Parasitic

Product Details:

Place of Origin: China
Brand Name: YC
Certification: ISO9001
Model Number: CAS:117704-25-3

Payment & Shipping Terms:

Minimum Order Quantity: 10grams
Price: 1USD
Packaging Details: 25KG/Drum
Delivery Time: 1-2days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 10000kg/month
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Detailed Product Description
Sample: Free Market: Global
Shipment: Safe Specification: 99%
Origin: China Synonyms: Doramectin Solution
High Light:

chlortetracycline hydrochloride

,

bethanechol chloride

Global Veterinary Medicine 99% 117704-25-3 Dectomax Doramectin for Antiparasitic

Basic Info

Model NO.: 117704-25-3
Name: Doramectin
CAS: 117704-25-3
Sample: Free
Market: Global
Shipment: Safe
Delivery: Door to Door Service
Trademark: YC
Transport Package: Express
Specification: 99%
Origin: China
HS Code: 2942000000

Product Description

Quick Detail for Doramectin
English Name: Doramectin
English Synonyms: doramectin; doramectin; doramectin; doramectin solution, 100PPM; 25-cyclohexyl-5-O-desmethyl-25-de(1-methylpropyl)avi Bacteriocin; doramectin; lactin; doramatin (doramectin)
CAS Number: 117704-25-3
Molecular Formula: C50H74O14
Molecular weight: 899.11
EINECS number: 1308068-626-2
Related categories: Antiparasitic; Intermediates & Fine Chemicals; Pharmaceuticals; Tetracyclines; IMIPEM; Microbial Metabolites; Pharmaceutical Intermediates; APIs; Organochlorine Insecticides; Macrolide Antibiotics; Insecticides; Acaricides; Veterinary drugs, veterinary antiparasites; small molecule inhibitors; Inhibitors; small molecule inhibitors

 


Introduction:


Doramectin is a new generation of anti-parasitic drugs. Compared with other commercially available ivermectin products, it has a wider range of antiparasitic effects, better efficacy, and effective time to prevent parasite reinfection. It is currently the best and most promising new veterinary antiparasitic drug in the world.

Doramectin is an internal and external parasite and killer, and is effective against both nematodes and arthropods. At present, the commonly used anthelmintic drugs in the pig industry in China are: endoparasitic drugs: albendazole, levamisole, trichlorfon, vinyomycin, hygromycin, ivermectin, abamectin. Parasitic drugs: trichlorfon, amitraz, diazinon, pyrethroids, abamectin, ivermectin.

 

Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinalroundworms, lungworms, eyeworms, grubs, sucking liceand mange mites in cattle.
Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A.(manufactured by Agrovet Market Animal Health) in an 1% Doramectin Long Acting Injectable Solution forcattle, sheep, swine and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.
Doramectin is also available for horses as an oral flavored bioadhesive gel under the name Doraquest L.A. Oral Gel.It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.

 


Usage:


It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes:Haemonchus spp., Ostertagia spp., Trichostrongylusspp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus,Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as aninjection and as a 5 mg/ml topical solution.


Efficacy of doramectin:


Doramectin is effective against the major parasitic roundworms: gastrointestinal and pulmonary. It is also effecive against most mites and lice species, and against numerous myiases (e.g. those caused by screwworm flies, bot flies and warble flies) usually regardless of the delivery form
Mechanism of Action:
As all macrocyclic lactone doramectin acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. It also affects the reproduction of some parasites by diminishing oviposition or inducing an abnormal oogenesis.
In mammals the GABA receptors occur only in the central nervous system (CNS), i.e. in the brain and the spinal chord. But mammals have a so-called blood-brain barrier that prevents microscopic objects and large molecules to get into the brain. Consequently macrocyclic lactones are much less toxic to mammals than to the parasites that do not have such a barrier, which allows quite high safety margins for use on livestock and pets. A notable exception to this are some dog breeds that carry the MDR-1 mutation.
Pharmacokinetics
Halftime for absorption into blood after injection in a sesame oil vehicle is shorter for goats (~0.7 days) than for cattle (~2.4 days) or sheep (~2.7 days).
Doramectin is well distributed throughout the whole body including target organs such as the gastric and gut mucosae. The highest concentrations are found in body fat that acts as a depot from where it is progressively released to blood. Bioavailability of doramectin after injection is almost 100%, but only about 18% after pour-on administration, which requires a higher dose. Excretion goes through bile and feces, 50 to 70% in the form of the unchanged parent molecule. The highest concentration in blood occurs 24 to 48 hours after administration.

Certificate of Analysis

 


Items

Specifications

Results

Appearance

Pale yellow crystalline powder

Pale yellow crystalline powder

Identification

HPLC: The retention time of major peak of test solution should correspond to that of reference solution.

Conforms

IR: Sample spectrum corresponds to that of standard spectrum.

Conforms

Appearance of Solution

The solution is clear and not more intensely colored than reference solution BY6

Conforms

Related Substances

Avermectin: NMT2.0%

0.8%

Total impurities: NMT5.0%

3.9%

Residual Solvents

Ethanol:NMT30000ppm

360ppm

Acetone: NMT5000ppm

140ppm

BHT

NMT2000ppm

316ppm

Sulphated Ash

NMT0.1%

0.07%

Heavy Metals

NMT20ppm

<20ppm

Water

NMT3.0%

1.8%

Assay(on anhydrous and solvent free basis)

≥95.0%

98.1%

 

 

 

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Discount Specials are possible when client's order is big
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Top Quality Veterinary Use Doramectin for Antiparasitic

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