CAS 2919 66 6 Progesterone Hormone Melengestrol Acetate 98% For Women Use White

(1)Product Basic Information

Description:
Melengestrol acetate (INN, USAN), sometimes abbreviated as MGA, is a steroidal progestin and antineoplastic agent.It is not approved for use in humans, and is instead used as a feed additive to promote growth in cattle, a purpose it is licensed for in the United States and Canada.It is an acetate ester of melengestrol, which in contrast, is not used in either animals or humans.


Quick details:
Product name: Melengestrol Acetate
CAS No.: 2919-66-6
EINECS: 220-859-7
MF: C25H32O4
MW: 396.57
Assay: 98%
Packing: as requirements
Appearance: light yellow crystalline powder
Usage:female hormone
 

Application:

Melengestrol acetat is widely used as a growth promoting feed additive in cattle breeding in the USA and several other non-European countries. To explore the physiological effects of MGA four heifers were fed during 8 weeks with 0.5 mg MGA daily as registered in the USA and two heifers each received 0, 1.5 or 5 mg/day, respectively. Plasma samples were collected twice a week and concentrations of MGA, progesterone and estradiol-17beta were quantified. The pulsatile secretion of luteinizing hormone was investigated in 6-hour profiles before and during treatment. After slaughter the reproductive organs were examined and oestrogen residues in edible tissues were measured.

Four days after the beginning of MGA feeding MGA concentrations in plasma reached levels of 30 and 100-400 pg/mL depending on the dose received. Three weeks after the beginning of MGA feeding P4 plasma concentrations had dropped to base levels below 0.3 ng/mL in all three treatment groups. Mean plasma E2-17beta levels increased in physiological range from 1 to 5 pg/mL during 0.5 mg MGA/day feeding with many acyclic peaks. Overdosed MGA decreased E2 levels and suppressed cyclic peaks. Number and size of ovarian follicles were not altered by any treatment. Mean LH levels and pulse frequencies increased significantly during labelled treatment , while higher doses had reducing effects. The development of corpus luteum was suppressed. E2-17beta residues in fat increased about 300% following labelled MGA treatment.
 

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