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Antidepressant Pharmaceutical Intermediates Nootropic Powder CAS 987 78 0 Cdp Choline Citicoline

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Antidepressant Pharmaceutical Intermediates Nootropic Powder CAS 987 78 0 Cdp Choline Citicoline

China Antidepressant Pharmaceutical Intermediates Nootropic Powder CAS 987 78 0 Cdp Choline Citicoline supplier
Antidepressant Pharmaceutical Intermediates Nootropic Powder CAS 987 78 0 Cdp Choline Citicoline supplier Antidepressant Pharmaceutical Intermediates Nootropic Powder CAS 987 78 0 Cdp Choline Citicoline supplier Antidepressant Pharmaceutical Intermediates Nootropic Powder CAS 987 78 0 Cdp Choline Citicoline supplier

Large Image :  Antidepressant Pharmaceutical Intermediates Nootropic Powder CAS 987 78 0 Cdp Choline Citicoline

Product Details:

Place of Origin: China
Brand Name: Simeiquan
Certification: IOS9001
Model Number: 2323

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Price: 10USD
Packaging Details: 25kg carton box
Delivery Time: 1-3 working days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg per month
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Detailed Product Description
CAS: 987-78-0 Name: Choline Citicoline
MF: C14H26N4O11P2 MW: 488.32
High Light:

pharmaceutical raw materials

,

pharmaceutical active ingredients

Product Name: CDP Choline Citicoline
Alias: CDP-Choline
CAS: 987-78-0
EINECS: 213-580-7
MF: C14H26N4O11P2
MW: 488.32
Purity: 99%
Grade: Pharmaceutical Grade
Appearance: White Powder

 

 

Description

 

CDP Choline Citicoline, also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.

 

CDP-choline is a nootropic compound that is essentially a prodrug for both choline and uridine, conferring both of those molecules to the body following oral ingestion of CDP-Choline. Specifically, the CDP-choline dissociates into choline and cytidine, with the cytidine then converting into uridine. CDP-choline is one of the three choline-containing phospholipids that can be orally supplemented (the other two being Alpha-GPC and phosphatidylcholine).

 

This supplement is catered towards preventing or treating memory impairments associated with aging due to the fact that both of the molecules it confers are neuroprotective and potentially enhance learning. While it appears to be more effective than phosphatidylcholine (PC) at this role, in part due to also increasing PC synthesis in the brain, its potency is somewhat comparable to that of Alpha-GPC.

 

Effects

 

Studies suggest that CDP-choline supplements increase dopamine receptor densities, and suggest that CDP-choline supplementation helps prevent memory impairment resulting from poor environmental conditions. Preliminary research has found that citicoline supplements help improve focus and mental energy.

 

Citicoline has also been shown to elevate ACTH independently from CRH levels and to amplify the release of other HPA axis hormones such as LH, FSH, GH and TSH in response to hypothalamic releasing factors. These effects on HPA hormone levels may be beneficial for some individuals but may have undesirable effects in those with medical conditions featuring ACTH or cortisol hypersecretion including PCOS, type II diabetes and major depressive disorder.

 

Memory Disorders

 

In a review of 14 clinical trials, the authors concluded there was evidence of benefit of citicoline on memory function and behaviour in patients suffering from cognitive deficits ranging from mild cognitive impairment to dementia. Dosing in most of the trials was 1000 mg/day. A more recent review reached the same conclusions, but went on to state that more clinical trials are needed to confirm its benefits.

 

Mechanism of Action

 

The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelin, preservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine, partial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.

 

Citicoline's effects may also be explained by the reduction of phospholipase A2 activity. Citicoline increases phosphatidylcholine synthesis. The mechanism for this may be: By converting 1, 2-diacylglycerol into phosphatidylcholine, stimulating the synthesis of SAMe, which aids in membrane stabilization and reduces levels of arachidonic acid. This is especially important after an ischemia, when arachidonic acid levels are elevated.

 

Dosage

 

Standard dosing of CDP-choline is to take 200-600mg in two divided doses usually separated by 8-12 hours, although a single daily dose is also sometimes used. There are some properties, such as attention-promotion or improving bioenergetics, that seem to respond exclusively or more strongly to the lower dosage range. Other properties like appetite are the opposite, and thus the ideal dosage depends somewhat on the goal.

 

Side Effects

 

Citicoline has a very low toxicity profile in animals and humans. Clinically, doses of 2000 mg per day have been observed and approved. Minor transient adverse effects are rare and most commonly include stomach pain and diarrhea.



Nootropics

 

Name CAS Purity
CDP-Choline 987-78-0 ≥98% HPLC
Citicoline sodium 33818-15-4 ≥98% HPLC
     
Coluracetam (MKC-231) 135463-81-9 ≥99.0% HPLC
     
Fasoracetam 110958-19-5 ≥99.0% HPLC
Galantamine Hydrobromide 1953-4-4 ≥99.0% HPLC
Huperzine A 102518-79-6 ≥1.0% and 99% HPLC
Armodafinil 112111-43-0 ≥99.0% HPLC
     
adrafinils 63547-13-7 ≥99.0% HPLC
Hydrafinil (9-Fluorenol) 1689-64-1 ≥99.0% HPLC
L-Alpha glycerylphosphorylcholine/ GPC 28319-77-9 50%, 99% HPLC
Phosphatidylserine 51446-62-9 ≥20%, 50% and 70% HPLC
L-α-Phosphatidylcholine 8002-43-5 70%, 50%
Magnesium L-Threonate 778571-57-6 ≥95.0% Titration
N-Acetyl-L-Tyrosine 537-55-3 98%~102% HPLC
Noopept 157115-85-0 ≥99.0% HPLC
Oxiracetam 62613-82-5 ≥99.0% HPLC
Phenibut 1078-21-3 ≥99.0% HPLC
Phenylpiracetam 77472-70-9 ≥99% HPLC
     
Pikamilone (Sodium) 62936-56-5 ≥98%~101%Titration
Piracetam 7491-74-9 ≥99.0% HPLC
     
Pramiracetam 68497-62-1 ≥98.0~102.0% HPLC
     
Sulbutiamine 3286-46-2 ≥98.0% HPLC
Sunifiram 314728-85-3 ≥99.5% HPLC
Tianeptine Hemisukfate Monohydrate,tianeptine sulfate 66981-73-5 ≥98.0%~102.0% HPLC
Tianeptine sodium 30123-17-2 ≥99.0% HPLC
     
Vincamine 1617-90-9 ≥99.0% HPLC
Vinpocetine 42971-09-5 ≥99.0% HPLC
PRL-8-53 51352-87-5 ≥99.0% HPLC
NSI-189 1270138-40-3 ≥99.0% HPLC
IDRA-21 22503-72-6 ≥99.0% HPLC
Mexidol 127464-43-1 ≥99.0% HPLC
agomelatine 138112-76-2 ≥99.0% HPLC
5a hydroxy laxogenin 56786-63-1 ≥99.0% HPLC
     
tadanafil 171596-29-5 ≥99.0% HPLC
avanafil 330784-47-9 ≥99.0% HPLC
     

 

4. Specification:

Name Specification
MGF 2mg/vials, 10 vials/box
PEG MGF 2mg/vials, 10 vials/box
CJC-1295 with DAC 2mg/vials, 10 vials/box
CJC-1295 without DAC 2mg/vials, 10 vials/box
PT-141 10mg/vials, 10 vials/box
MT-1 10mg/vials, 10 vials/box
MT-2 10mg/vials, 10 vials/box
GHRP-2 5mg/vials, 10 vials/box
GHRP-2 10mg/vials, 10 vials/box
GHRP-6 5mg/vials, 10 vials/box
GHRP-6 10mg/vials, 10 vials/box
Ipamorelin 2mg/vials, 10 vials/box
Hexarelin 2mg/vials, 10 vials/box
Sermorelin 2mg/vials, 10 vials/box
Oxytocin 2mg/vials, 10 vials/box
TB500 2mg/vials, 10 vials/box
pentadecapeptide BPC 157 2mg/vials, 10 vials/box
Hg 176-191 2mg/vials, 10 vials/box
Triptorelin 2mg/vials, 10 vials/box
Tesamorelin 2mg/vials, 10 vials/box
Gonadorelin 2mg/vials, 10 vials/box
Gonadorelin 10mg/vials, 10 vials/box
DSIP 2mg/vials, 10 vials/box
Selank 5mg/vials, 10 vials/box

 

 

Name Specification
MGF 2mg/vial
PEG MGF 2mg/vial
CJC-1295 with DAC 2mg/vial
CJC-1295 without DAC 2mg/vial
PT-141 10mg/vial
MT-1(Melanotan) 10mg/vial
MT-2 10mg/vial
GHRP-2 5mg/vial
GHRP-2 10mg/vial
GHRP-6 5mg/vial
GHRP-6 10mg/vial
Ipamorelin 2mg/vial
Hexarelin 2mg/vial
Sermorelin 2mg/vial
Oxytocin 2mg/vial
TB500 2mg/vial
pentadecapeptide BPC 157 2mg/vial
176-191 2mg/vial
Triptorelin 2mg/vial
Tesamorelin 2mg/vial
Gonadorelin 2mg/vial
Gonadorelin 10mg/vial
DSIP 2mg/vial
Selank 5mg/vial

 

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Growth Hormne Peptides

T-A001 MGF 2mg
T-A002 PEG MGF 2mg
T-A003 CJC-1295 with DAC 2mg
T-A004 CJC-1295 without DAC 2mg
T-A005 PT-141 10mg
T-A006 MT-1(Melanotan-1) 10mg
T-A007 MT-2(Melanotan-2) 10mg
T-A008 GHRP-2 5mg
T-A008 GHRP-2 10mg
T-A009 GHRP-6 5mg
T-A009 GHRP-6 10mg
T-A0010 Ipamorelin 2mg
T-A0011 Hexarelin 2mg
T-A0012 Sermorelin 2mg
T-A0013 Oxytocin 1g
T-A0014 TB500 2mg
T-A0015 pentadecapeptide BPC 157 2mg
T-A0016   2mg
T-A0017 Triptorelin 2mg
T-A0018 Tesamorelin 2mg
T-A0020 Gonadorelin 2mg
T-A0020 Gonadorelin 10mg
T-A0021 DSIP 2mg
T-A0022 Selank 5mg
T-A0023 Epitalon 10mg



 

Peptides Specification
MGF 2mg
PEG MGF 2mg
CJC-1295 with DAC 2mg
CJC-1295 without DAC 2mg
PT-141 10mg
MT-1 10mg
MT-2 10mg
GHRP-2 5mg
GHRP-2 10mg
GHRP-6 5mg
GHRP-6 10mg
Ipamorelin 2mg
Hexarelin 2mg
Sermorelin 2mg
Oxytocin 2mg
TB500 2mg
Pentadecapeptide BPC 157 2mg
Triptorelin 2mg
Tesamorelin 2mg
Gonadorelin 2mg
Gonadorelin 10mg
DSIP 2mg
Selank 5mg




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-------------------------------- Additional Information -------------------------------
Place of origin : China
Brand : SMQ
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Production capacity : 1000 Kilograms/Month

-------------------------------- Delivery Information ---------------------------------
Packing : Foil bag/tin or as your request
Payment : T/T, Western Union, MoneyGram
Port : Shanghai, Shenzhen, Hongkong
Shipment method : EMS, DHL, FeDex, UPS, etc
Leading time : Within 24 hours after payment
Delivery time : Within 6 business days after payment (door to door service)
-------------------------------- Our Competitive Advantages ---------------------------
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2. We send the detailed price of our product and offer the suitable shipping method for your reference.
3. You confirm the order and pay money 100% in advance and send us the detailed address.
4.We will pack your parcel and arrange to shipment according to your requirements
5.Once parcel is sent,I will offer you parcel's picture,tracking number and tracking website.
6.After you receiving parcel,we will offer you best after-sale.
 

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