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Androgen Steroids Anti Estrogen Drugs CAS 118237-47-0 Rad -140 For Bodybuilding

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Androgen Steroids Anti Estrogen Drugs CAS 118237-47-0 Rad -140 For Bodybuilding

China Androgen Steroids Anti Estrogen Drugs CAS 118237-47-0 Rad -140 For Bodybuilding supplier
Androgen Steroids Anti Estrogen Drugs CAS 118237-47-0 Rad -140 For Bodybuilding supplier Androgen Steroids Anti Estrogen Drugs CAS 118237-47-0 Rad -140 For Bodybuilding supplier Androgen Steroids Anti Estrogen Drugs CAS 118237-47-0 Rad -140 For Bodybuilding supplier

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Product Details:

Place of Origin: China
Brand Name: Simeiquan
Certification: IOS9001
Model Number: 234234

Payment & Shipping Terms:

Minimum Order Quantity: 10vials
Price: 10USD
Packaging Details: Disguised package
Delivery Time: 1-3 working days
Payment Terms: Western Union, MoneyGram, T/T
Supply Ability: 10000vials per week
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Detailed Product Description
Name: Rad-140 Type: Weight Loss
Warranty: 1 Year Color: White
CAS: N/A Weight: 10vials
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epinephrine hydrogen tartrate


l noradrenaline bitartrate

The androgen receptor (AR) is a member of the steroid hormone nuclear receptor superfamily that includes estrogen, progestin, glucocorticoid and mineralocorticoid receptors.1 The binding of the prototypical, endogeneously produced androgen(1) and the important active metabolite (2) to AR initiates a remarkably diverse array of biological activities that can vary according to a subject's sex, age and hormonal status. The activity of AR is critical to normal human sexual development and function, but beyond this signature role, AR activation also has important effects on diverse targets such as bone, liver, muscle and the central nervous system.2,3 The therapeutic potential of androgen signaling is well-appreciated in the medicinal chemistry community, and for quite some time, chemists have sought compounds that selectively stimulate muscle and bone growth while minimizing the proliferative and/or hypertrophic effects on sex tissues such as the prostate in males and clitoris in females.4,5 Such compounds have been termed selective androgen receptor modulators or SARMs. In this regard, the prototypical and endogenous androgen,, is considered to be a logical benchmark comparator. Compound 3 is the GTx SARM S-22 and compound 4 is the BMS SARM 562929, both of which have been reported in the literature as being orally active compounds with selectivity for muscle over prostate relative to in various preclinical models.6,7
The possibility of obtaining compounds having tissue-selective activities that are different from that of the endogenous benchmark might derive from the fact that typical AR receptor activation, which is initiated by the binding of a molecule with affinity for the AR to the AR ligand binding domain, is then followed by a rather remarkable, coordinated series of interactions: These may include a change in receptor topology, dissociation of heat shock proteins, receptor dimerization, receptor phosphorylation, rapid-signaling events, translocation to the nucleus (AR), association with many different coregulatory proteins to form a transcriptional complex that results in the activation or suppression of RNA synthesis from AR-modulated genes, and finally receptor degradation.8 Since each receptorligand complex topology is unique to that ligand structure, one can appreciate that the interaction of any particular ligandreceptor complex with coregulatory proteins is likely to be unique to that ligand as well. Furthermore, because the expression level of AR, the constellation and expression level of coregulatory proteins, and the patterns of post-transcriptional regulatory events differ in each type of androgen target cell, and the topography of AR regulatory sites in the genome differs at each gene, this remarkable choreography of events and interactions provides a rich environment within which one might search for SARMs having a desirable pattern of tissue-selective pharmacology, such as high anabolic but limited androgenic activity.
Further complicating our understanding of the origin of SARM selectivity is the "bio-amplification" of the primary endogenous androgen Interestingly, the endogenously produced and very important androgen serves as a type of "anti-SARM" or "inverse SARM" because its androgenic activity is increased by conversion to the more potent by the 5α-reductase enzyme in certain tissues including the scalp and prostate (but not in muscle or bone). As a result, androgens that do not undergo such bioamplification in the prostate will demonstrate improved selectivity regarding muscle vs prostate when compared to a -treated control or an intact animal whose primary endogenous androgen is 9 More broadly put, one might appreciate that metabolic differences between endogenous androgens such as and SARMs can also vouch for at least some selectivity differences.
Our work in the SARM area resulted in the synthesis and evaluation of a large number of candidate templates. While we found it relatively easy to obtain compounds with high affinity for AR, we struggled to achieve compounds that demonstrated good oral efficacy and high in vivo tolerability. After scanning many potential leads for oral, in vivo activity, we arrived at high affinity compound 5 through a combination of synthetic intermediate testing, literature evaluation and fragment combination. We were delighted when 5 demonstrated oral activity in rats.
However, when we performed a pharmacokinetic analysis in rats, we could detect only very low levels of 5 after oral dosing (F < 5%). Further analysis revealed that 5 was efficiently converted to 6in vivo, presumably by cytochromes P450 in the rat liver.10 Compound 6 had similar activity to compound 5in vivo, suggesting that 6was largely responsible for the activity of compound 5.11 An in vitro screen with human microsomes revealed rapid metabolism of compound 5, thus indicating this transformation as a potential human metabolic liability and prompting us to prepare compounds in which the 4′-position of the pendant phenyl was blocked from P450-induced hydroxylation.12 We looked at several analogues containing a 4′-blocking group, and in the course of our efforts we identified compound 7 (RAD140; Figure Figure1)1) as our preclinical development candidate.



Name Specification
MGF 2mg/vial
PEG MGF 2mg/vial
CJC-1295 with DAC 2mg/vial
CJC-1295 without DAC 2mg/vial
PT-141 10mg/vial
MT-1(Melanotan) 10mg/vial
MT-2 10mg/vial
GHRP-2 5mg/vial
GHRP-2 10mg/vial
GHRP-6 5mg/vial
GHRP-6 10mg/vial
Ipamorelin 2mg/vial
Hexarelin 2mg/vial
Sermorelin 2mg/vial
Oxytocin 2mg/vial
TB500 2mg/vial
pentadecapeptide BPC 157 2mg/vial
176-191 2mg/vial
Triptorelin 2mg/vial
Tesamorelin 2mg/vial
Gonadorelin 2mg/vial
Gonadorelin 10mg/vial
DSIP 2mg/vial
Selank 5mg/vial


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Growth Hormne Peptides

T-A001 MGF 2mg
T-A002 PEG MGF 2mg
T-A003 CJC-1295 with DAC 2mg
T-A004 CJC-1295 without DAC 2mg
T-A005 PT-141 10mg
T-A006 MT-1(Melanotan-1) 10mg
T-A007 MT-2(Melanotan-2) 10mg
T-A008 GHRP-2 5mg
T-A008 GHRP-2 10mg
T-A009 GHRP-6 5mg
T-A009 GHRP-6 10mg
T-A0010 Ipamorelin 2mg
T-A0011 Hexarelin 2mg
T-A0012 Sermorelin 2mg
T-A0013 Oxytocin 1g
T-A0014 TB500 2mg
T-A0015 pentadecapeptide BPC 157 2mg
T-A0016   2mg
T-A0017 Triptorelin 2mg
T-A0018 Tesamorelin 2mg
T-A0020 Gonadorelin 2mg
T-A0020 Gonadorelin 10mg
T-A0021 DSIP 2mg
T-A0022 Selank 5mg
T-A0023 Epitalon 10mg


Peptides Specification
MGF 2mg
CJC-1295 with DAC 2mg
CJC-1295 without DAC 2mg
PT-141 10mg
MT-1 10mg
MT-2 10mg
GHRP-2 5mg
GHRP-2 10mg
GHRP-6 5mg
GHRP-6 10mg
Ipamorelin 2mg
Hexarelin 2mg
Sermorelin 2mg
Oxytocin 2mg
TB500 2mg
Pentadecapeptide BPC 157 2mg
Triptorelin 2mg
Tesamorelin 2mg
Gonadorelin 2mg
Gonadorelin 10mg
DSIP 2mg
Selank 5mg

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-------------------------------- Additional Information -------------------------------
Place of origin : China
Brand : SMQ
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Production capacity : 1000 Kilograms/Month

-------------------------------- Delivery Information ---------------------------------
Packing : Foil bag/tin or as your request
Payment : T/T, Western Union, MoneyGram
Port : Shanghai, Shenzhen, Hongkong
Shipment method : EMS, DHL, FeDex, UPS, etc
Leading time : Within 24 hours after payment
Delivery time : Within 6 business days after payment (door to door service)
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