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99% Min Sarms Raw Powder Gw-0742 / Gw610742 CAS 317318 84 6 Pharmaceutical Material

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99% Min Sarms Raw Powder Gw-0742 / Gw610742 CAS 317318 84 6 Pharmaceutical Material

China 99% Min Sarms Raw Powder Gw-0742 / Gw610742 CAS 317318 84 6 Pharmaceutical Material supplier
99% Min Sarms Raw Powder Gw-0742 / Gw610742 CAS 317318 84 6 Pharmaceutical Material supplier 99% Min Sarms Raw Powder Gw-0742 / Gw610742 CAS 317318 84 6 Pharmaceutical Material supplier 99% Min Sarms Raw Powder Gw-0742 / Gw610742 CAS 317318 84 6 Pharmaceutical Material supplier

Large Image :  99% Min Sarms Raw Powder Gw-0742 / Gw610742 CAS 317318 84 6 Pharmaceutical Material

Product Details:

Place of Origin: China
Brand Name: Simeiquan
Certification: IOS9001
Model Number: 325435

Payment & Shipping Terms:

Minimum Order Quantity: 100g
Price: 10USD
Packaging Details: Disguisesd package
Delivery Time: 1-3 working days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 10000L per week
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Detailed Product Description
Name: Gw610742 Form: Powder
CAS: 317318-84-6 Purity: 99%min
Material: Pharmaceutical Material
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CAS Number. 317318-84-6
chemical name GW0742/GW610742
Synonyms GW0742;GW 0742X;GW 610742;GWdelta 0742;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]AceticAcid;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid;Acetic acid, 2-[4-[[[2-[3-fluoro-4-(trifluoroMethyl)phenyl]-4-Methyl-5-thiazolyl]Methyl]thio]-2-Methylphenoxy]-
CBNumber: CB4138491
MF C21H17F4NO3S2
MW 471.49
Melting Point 134.5-135.5 °C
Storage Temperature 2-8°C
Solubility DMSO: >5 mg/mL


GW0742 / GW610742 Description:
GW0742, also known as GW610742, is a PPARδ/β agonist. GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons. GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. GW0742 has direct protective effects on right heart hypertrophy.GW0742 may enhance lipid metabolism in heart both in vivo and in vitro.GW0742 / GW610742 Biological Activity:

GW0742 / GW610742 is a potent and highly selective PPARδ agonist. EC50 values are 1nM, 1.1μM and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively.
GW0742 is a synthetic high affinity PPAR β/δ agonist, and its possible role in preventing the advance of inflammatory and apoptotic processes induced by bleomycin, that long-term leads to the appearance of pulmonary fibrosis. Our data showed that GW0742-treatment (0.3 mg/Kg, 10 percent DMSO, i.p.) has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of:cytokine production; leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (MPO) activity; IkBα degradation and NF-kB nuclear translocation; ERK phosphorylation; stress oxidative by NO formation due to iNOS expression; nitrotyrosine and PAR localization; the degree of apoptosis, evaluated by Bax and Bcl-2 balance, FAS ligand expression and TUNEL staining. Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO--instillation in mice.

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